Peking University People’s Hospital Reports the First Isolate
Recently, the international journal Emerging Microbes & Infections has reported the first isolate of Candida auris, the “super fugus”. The research was a collaboration of Professor Wang Hui’s team at the Department of Clinical Laboratory, Peking University People’s Hospital (PKUPH), and Researcher Huang Guanghua’s team at the State Key Laboratory of Mycology of Institute of Microbiology, Chinese Academy of Sciences. The research made a systematic analysis of the clinical and biological features of C. auris BJCA001, and studied its morphological phenotypes, susceptibility to antifungal agents, and virulence.
This first isolate of C. auris in China was initially identified by applying in-house MALDI-TOF MS database and verified by the internal transcribed spacers (ITS) by PKUPH’s Laboratory of Microbiology. This C. auris is closely related to the strains reported in India, Pakistan, and France. The research also found C. auris could grow at high salt concentrations and temperatures, with different morphologies in different growth media. In both mouse and Galleria mellonella infection models, C. auris was found to be much less virulent than C. albicans, which is more common clinically. The research provided new ideas for clinical prevention and treatment of the infection of “super fungus” in our country, and new methods for international peer biological research on this fungal species.
Written by: Lang Lang
Edited by: Liu Xin
Source: PKU People’s Hospital