Peking University Sixth Hospital Finds New Strategy against Opioid Use Disorder
A research group at Peking University Sixth Hospital developed and validated a new strategy to treat opioid use disorder (OUD), a severe global health issue that causes disability, death and transmission of infectious diseases. The new strategy uses methadone-initiated memory reconsolidation updating procedure (MMRUP) as opposed to MRUP initiated by abused drugs. The article (YueJL et al., The effect of a methadone-initiated memory reconsolidation updating procedure in opioid use disorder: A translational study. eBioMedicine2022;85:104283. https://doi.org/10.1016/j.ebiom.2022.104283) was published online September 22 on eBioMedicine.
The new strategy was based on a series of studies conducted by the same research group led by Prof. Lu Lin. Previously, the group had proposed memory reconstruction interventions triggered by conditioned and unconditioned stimulus, which could decrease craving and reduce relapse risk by erasing drug-associated memories in human and animal studies. These studies had been published on Science in 2012, Nature Communications in 2015 and JAMA Psychiatry in 2017.
Written by: Fan Xiaofei
Edited by: Liu Xin
Source: Peking University Sixth Hospital