Nature Cell Biology Publishes Latest Research on Human Early Embryos by Academician Qiao Jie Team
On June 18, Academician Qiao Jie’s team from Peking University Third Hospital and Researcher Tang Fuchou’s team from PKU College of Life Sciences published their latest research on human early cell on Nature Cell Biology (IF="20.06)" online with the title “Single-cell Multi-Omics Sequencing of Human Early Embryos”. The research applied single-cell chromatin overall omic-scale landscape sequencing (scCOOL-seq), the world’s leading technology, and generated for the first time a genome-wide map of DNA methylation and chromatin accessibility at single-cell resolution during human preimplantation development. The research made a further analysis of the complex but coordinated epigenetic reprogramming during human preimplantation development.
Academician Qiao Jie’s team and Researcher Tang Fuchou’s team have been collaborating closely for a long time, committed to uncovering gene expression and epigenetic regulatory network. They’ve conducted a complete single-cell RNA-Seq profiling of human preimplantation embryos (Nature Structural & Molecular Biology, 2013), and systematically analyzed the DAN methylation in the development of human early embryos and primordial germ cells (Nature, 2014; Cell, 2015), providing very important evidence for further understanding human embryonic development and the molecular mechanism during the generation of gametes.
The study applied scCOOL-seq to systematically analyze DNA methylation and chromatin accessibility in human preimplantation embryos, which enhanced the understanding of human embryonic epigenetic reprogramming. The study revealed for the first time the asymmetric distributions of DNA methylation and chromatin in paternal and maternal genomes in human early embryos. Besides, with a quantitative comparison between the chromatins in human and mice embryos, the study also found epigenetic features of species conservativeness and specification, which laid a theoretical foundation for future research on epigenetics in human and mice early embryos by clarifying the advantages and limitations of using mice as a model organism to study mammal early development. The research offered new thoughts and methods for clinical exploration, diagnosis and treatment of embryonic development block, implantation failure, and repetitive miscarriages.
Written by: Lang Lang
Edited by: Liu Xin
Source: PKU Third Hospital