Nanping Wang, Ph.D.
Professor of Physiology
Postal Address：Institute of Cardiovascular Sciences,
Peking University Health Science Center, Beijing 100083, China
Dr. Nanping Wang is a professor and associate director of the Institute of Cardiovascular Science and Diabetes Center, Peking University. He graduated from Xi’an Medical University with his medical degree in 1986. Sponsored by the Sasakawa Health Foundation, he completed his medical fellowship on autoimmune diseases in Kitasato University, Japan in 1990. In 1994, he received his Ph.D degree from Beijing Medical University and, then, conducted research in molecular genetics as a visiting scientist at Benjamin Franklin Medical Center, Free University Berlin, Germany. From 1995 to 2000, he received postdoctoral training in molecular immunology at Indiana University-Purdue University Indianapolis (IUPUI) and in vascular biology at University of California. Since 2000, he held appointments as a research assistant professor in Biomedical Sciences at UC Riverside and in Bioengineering at UC San Diego. He has been a member of many professional societies including American Heart Association (AHA), American Society for Biochemistry and Molecular Biology (ASBMB), North American Vascular Biology Organization (NAVBO) and American Diabetes Association (ADA). Since 2003, he has been a professor in the Institute of Cardiovascular Sciences, Peking University. He also holds an adjunct professorship in the Departments of Physiology and Pathophysiology. Major research interests in Dr. Wang’s laboratory include vascular biology, functional genomics; mechanotransduction and molecular pathogeneses of atherosclerosis and diabetes. Their ongoing projects are supported by grants from the National Science Foundation and the Ministry of Education.
- Wang, N., Verna, L., Hardy, S., Forsayeth, J., Zhu, Y., Ma, K.S., Stemerman, M.B. Adenovirus-mediated overexpression of c-Jun and c-Fos induces intercellular adhesion molecule-1 and monocyte chemo-attractant protein-1 in human endothelial cells. Arterioscler Thromb Vasc Biol. 1999; 19:2078-2084
2. Zhu, Y., Liao, H.L., Wang, N., Friedli, O., Verna, L., Stermerman, M.B. Low-density lipoprotein activates Jun N-terminal kinase (JNK) in human endothelial cells. Biochimica et Biophisica Acta 1999; 1436:557-64
3. Wang, N., Verna, L., Hardy, S., Ma, K., Zhu, Y., Birrer, MJ., Stemerman, M.B. c-Jun triggers apoptosis in human vascular endothelial cells. Circ Res. 1999; 85: 387-393
4. Liao, H.L., Zhu, Y., Wang, N., Verna, L., Stemerman, M.B. Selective activation of endothelial cells by the antioxidant pyrrolidine dithiocarbamate: involvement of c-Jun and Jun N-terminal kinase activation. Endothelium 2000; 7:121-133
5. Zhu, Y., Liao, H., Wang, N., Yuan, Y., Ma, K., Verna, L., Stemerman, MB. Lipoprotein promotes caveolin-1 and ras translocation to caveolae. Role of cholesterol in endothelial signaling. Arterioscler Thromb Vasc Biol. 2000; 20:2465-2470
6. Zhu, Y., Liao, H., Wang, N., Ma, K., Verna, L., Shyy, J., Chien, S., Stemerman, MB. Low-density lipoprotein-activated p38 is mediated by ras. Arterioscler Thromb Vasc Biol. 2001; 21:1159
7. Wang, N., Verna, L., Zhu, Y., Liao, H., Ballard, A., Stemerman, MB. Adenovirus-mediated overexpression of a dominant negative mutant of c-Jun prevents intercellular adhesion molecule-1 induction by LDL-A critical role for AP-1 in endothelial activation. Arterioscler Thromb Vasc Biol. 2001; 21: 1414-1420
8. Yuan, Y., Verna, L., Wang, N., Liao, H., Ma, K., Wang, Y., Zhu, Y., Stemerman, MB. Cholesterol enrichment induces intercellular adhesion molecule-1 in human vascular endothelial cells. Biochimica et Biophisica Acta. 2001; 1534: 139-48
9. Wang, N., Stemerman, MB. Ref-1 and transcriptional control of endothelial apoptosis. Circ Res 2001; 88:1223 –1225（Editorial）
10. Wang, N., Verna, L., Chen, N., Chen, J., Li, H, Forman, B.M., Stemerman, MB. Constitutive activation of PPAR-suppresses expression of adhesion molecules in vascular endothelial cells. J Biol Chem 2002; 277: 34176-34181
11. Wang, N. Cell Adhesion Molecules (CAMs). Encyclopedia of the Neurological Sciences, (Aminoff, MJ., and Daroff, RB, ed) Vol. 1, pp 541-542, Academic Press, San Diego, 2003
12. Wu J, Zhang Y, Wang N, Davis L, Yang G, Wang X, Zhu Y, Breyer MD, Guan Y. Liver X receptor alpha (LXRalpha) mediates cholesterol efflux in glomerular mesangial cells. Am J Physiol Renal Physiol. 2004; 287:F886-895
13.Liu,Y., Zhu, Y., Rannou, F., Lee, T-S., Formentin, K., Zeng, L., Yuan, X., Wang, N., Chien, S., Forman, B.,Shyy, Y-J. Laminar flow activates peroxisome proliferator-activated receptor-in vascular endothelial cells. Circulation 2004; 28-1133
14. Yan H, Guo Y, Zhang P, Zu L, Dong X, Chen L, Tian J, Fan X, Wang N, Wu X,Gao W. Superior neovascularization and muscle regeneration in ischemic skeletal muscles following VEGF gene transfer by rAAV1 pseudotyped vectors. Biochem Biophys Res Commun. 2005; 26:336:287-298
15. Zhu Y, Liao H, Xie X, Yuan Y, Lee TS, Wang N, Wang X, Shyy JY, Stemerman MB. Oxidized LDL downregulates ATP-binding cassette transporter-1 in human vascular endothelial cells via inhibiting liver X receptor (LXR). Cardiovasc Res. 2005; 68:425-32
16. Zhang P, Wang N. Adipokines and Metabolic Syndrome. Basic Med & Clin, 2006, 26:20-26.
17. Wu, C, Li ,Y ,. Haga, J, Wang,N, Lian, I, Su, F, Usami, S and S Chien. Roles of MAP kinases in the regulation of bone matrix gene expressions in human osteoblasts by oscillatory fluid flow. J Cell Biochem. 2006 Jan 26; [Epub ahead of print]
18. Wang,N.; Miao,H.; Li,Y.S.; Zhang,P.; Haga,J.H.; Hu,Y.; Young,A.; Yuan,S.; Nguyen,P.; Wu,C.C.; Chien,S. Shear stress regulation of Kruppel-like factor 2 expression is flow pattern-specific. Biochem Biophys Res Commun. 2006; 341:1244-1251
19. Wu,X.; Ma,J.; Han,J.D.; Wang,N.; Chen,Y.G. Distinct regulation of gene expression in human endothelial cells by TGF-beta and its receptors. Microvasc.Res.2006; 71:12-9